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NEET2026BiologyChapterActual

Given below are two statements: Statement I: In the first clinical gene therapy for Adenosine deaminase (ADA) deficiency, lymphocytes from the blood of the patient were extracted and grown in a culture outside the body. Statement II: A functional ADA cDNA was introduced into these cultured lymphocytes using an Agrobacterium vector, before returning the cells to the patient's body. In the light of the above statements

Options

  1. ABoth Statement I and Statement II are true.
  2. BBoth Statement I and Statement II are false.
  3. CStatement I is true but Statement II is false.
  4. DStatement I is false but Statement II is true.

Correct answer

C. Statement I is true but Statement II is false.

Step-by-step solution

Statement I is true because in the first clinical gene therapy for Adenosine deaminase deficiency, lymphocytes from the blood of the patient were extracted and grown in a culture outside the body. Statement II is false because a retroviral vector, rather than an Agrobacterium vector, is used to introduce the functional ADA cDNA into the cultured human lymphocytes. Agrobacterium vectors are used for transferring genes into plant cells, not animal cells. Thus, Statement I is true but Statement II is false.

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