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NEET2026BiologyChapterActual

In the Citric Acid Cycle, a molecule of GTP is synthesised during the conversion of:

Options

  1. A-ketoglutaric acid to succinyl-CoA
  2. BSuccinyl-CoA to succinic acid
  3. CSuccinic acid to fumaric acid
  4. DFumaric acid to malic acid

Correct answer

B. Succinyl-CoA to succinic acid

Step-by-step solution

In the Citric Acid Cycle (Krebs cycle), the conversion of succinyl-CoA to succinic acid is coupled with the substrate-level phosphorylation of GDP to GTP. During this reaction, the high-energy thioester bond of succinyl-CoA is cleaved, and the energy released is used to synthesize GTP from GDP and inorganic phosphate. The other steps mentioned involve different energy carriers: -ketoglutaric acid to succinyl-CoA produces NADH. Succinic acid to fumaric acid produces FADH ₂ . Fumaric acid to malic acid involves the a

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