A chemosensitive area is situated adjacent to the respiratory rhythm centre in the human brain. This area is highly sensitive to an increase in the concentration of:

Step-by-step solution

A chemosensitive area is situated adjacent to the respiratory rhythm centre in the medulla region of the human brain. This area is highly sensitive to changes in the concentration of CO₂ and hydrogen ions ( H^+ ). An increase in CO₂ and H^+ activates this centre, which in turn signals the rhythm centre to make necessary adjustments in the respiratory process to eliminate these substances. The role of oxygen in the regulation of respiratory rhythm is quite insignificant. Answer: CO₂ and hydrogen ions