The following events occur during the life cycle of Plasmodium . Arrange these events in the correct sequential order. A. Fertilisation and development of the parasite take place in the mosquito's gut. B. Rupture of RBCs and release of a toxic substance called haemozoin. C. Sporozoites escape from the gut and migrate to the salivary glands. D. Differentiation of the parasite into sexual stages (gametocytes) within th

Step-by-step solution

The life cycle of Plasmodium follows a specific sequence of events in both the human host and the mosquito vector. First, the parasite multiplies asexually in the red blood cells (RBCs), leading to their rupture and the release of a toxic substance called haemozoin, which is responsible for the chill and high fever (Event B). Following this, some of the parasites differentiate into sexual stages known as gametocytes within the red blood cells (Event D). When a female Anopheles mosquito bites an infected person, it