MHT CET Medical202623 April 2026Morning ShiftChemistryAminesActual
Which of the following methods is the most convenient method to prepare an amine containing one carbon atom less than the parent compound?
Options
- AReduction of Isonitriles
- BHofmann bromamide reaction
- CGabriel phthalimide synthesis
- DReductive amination of aldehydes.
Correct answer
B. Hofmann bromamide reaction
Step-by-step solution
Hofmann bromamide degradation reaction is used for the preparation of primary amines from primary amides. In this reaction, a primary amide is treated with bromine in an aqueous or ethanolic solution of sodium hydroxide. The general reaction is given by: R-CONH₂ + Br₂ + 4NaOH R-NH₂ + Na₂CO₃ + 2NaBr + 2H₂O The resulting primary amine contains one carbon atom less than the parent amide due to the loss of the carbonyl carbon as sodium carbonate. Thus, it is the most convenient method to prepare an amine containing one