NEET2008ChemistryElectrochemistryActual
The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of
Options
- AAcyl chloride > Acid anhydride > Ester > Amide
- BEster > Acyl chloride > Amide > Acid anhydride
- CAcid anhydride > Amide > Ester > Acyl chloride
- DAcyl chloride > Ester > Acid anhydride > Amide
Correct answer
A. Acyl chloride > Acid anhydride > Ester > Amide
Step-by-step solution
Key Idea : The ease of nucleophilic substitution is depend upon the nature of leaving group. When the leaving tendency of a group in a compound is high, then the compound is more reactive towards nucleophilic substitution. The nucleophilic acyl substitution is completed in two steps as shown below The reactivity of the compound may be explained on the basicity of the leaving group. A weaker base is a better leaving group. The basicity order is as : Cl ⁻> RCOO ⁻> RO ⁻> NH ₂⁻ Hence, the order of leaving tendency is C