NEETZoologyBiotechnology and Its Applications
What is the C peptide present in insulin?
Options
- AA chain of human insulin
- BB chain of human insulin
- CExtra stretch
- DDisulphide bridges
Correct answer
C. Extra stretch
Step-by-step solution
In mammals, including humans, insulin is synthesized as a pro-hormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.The main challenge for production of insulin using rDNA techniques was getting insulin assembled into a mature form. In 1983, Eli Lilly an American company prepared two DNA seque