NEETZoologyBiotechnology and Its Applications
What is the role of pro-hormone in insulin synthesis?
Options
- AIt is processed before becoming a fully mature and functional hormone.
- BIt contains an extra stretch called the C peptide.
- CIt is not present in mature insulin.
- DIt is used to produce insulin chains.
Correct answer
A. It is processed before becoming a fully mature and functional hormone.
Step-by-step solution
In mammals, including humans, insulin is synthesized as a pro-hormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.The main challenge for production of insulin using rDNA techniques was getting insulin assembled into a mature form. In 1983, Eli Lilly an American company prepared two DNA seque