NEETZoologyBiotechnology - Principles and Processes
What is the result of transforming recipient cells with recombinant DNA bearing a gene for resistance to an antibiotic?
Options
- AThe recipient cells will not be affected by the antibiotic
- BThe recipient cells will be more susceptible to the antibiotic
- CThe recipient cells will have increased resistance to the antibiotic
- DThe recipient cells will become completely resistant to the antibiotic
Correct answer
C. The recipient cells will have increased resistance to the antibiotic
Step-by-step solution
There are several methods of introducing the ligated DNA into recipient cells. Recipient cells after making them ‘competent’ to receive, take up DNA present in its surrounding. So, if a recombinant DNA bearing gene for resistance to an antibiotic (e.g., ampicillin) is transferred into E. coli cells, the host cells become transformed into ampicillin-resistant cells. If we spread the transformed cells on agar plates containing ampicillin, only transformants will grow, untransformed recipient cells will die. Since, du