NEETZoologyBiotechnology - Principles and Processes
In pBR322, ampR and tetR genes are present. When we ligate a foreign DNA at Pst-I site, then recombinant plasmids will lose the resistance to the
Options
- AAmpicillin
- BTetracycline
- CBoth (1) and (2)
- DNone of the above
Correct answer
A. Ampicillin
Step-by-step solution
The recombinant plasmids will lose tetracycline resistance due to insertion of foreign DNA but can still be selected out from non-recombinant ones by plating the transformants on tetracycline containing medium. The transformants growing on ampicillin containing medium are then transferred on a medium containing tetracycline. The recombinants will grow in ampicillin containing medium but not on that containing tetracycline. But, non- recombinants will grow on the medium containing both the antibiotics.