NEETZoologyBiotechnology - Principles and Processes
Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): In gene therapy for ADA deficiency, the introduction of functional ADA cDNA into the patient's cultured lymphocytes provides a permanent cure. Reason (R): Lymphocytes are not immortal cells, hence the patient requires periodic infusion of such genetically engineered lymphocytes. In the light of the
Options
- ABoth (A) and (R) are true and (R) is the correct explanation of (A)
- BBoth (A) and (R) are true but (R) is not the correct explanation of (A)
- C(A) is true but (R) is false
- D(A) is false but (R) is true
Correct answer
D. (A) is false but (R) is true
Step-by-step solution
Assertion (A) is false because the introduction of functional ADA cDNA into cultured lymphocytes does not provide a permanent cure. A permanent cure is only possible if the gene isolated from bone marrow cells producing ADA is introduced into cells at early embryonic stages. Reason (R) is true because lymphocytes are not immortal cells. Since they have a limited lifespan, the patient requires periodic infusion of the genetically engineered lymphocytes to maintain functional ADA levels. Answer: (A) is false but (R)