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NEET 2026
Exam
NEET
Year
2026
Subject
Biology
Chapter
Chapter

NEET 2026 · Biology · Chapter

A phenotypically normal woman, whose father suffered from...

A phenotypically normal woman, whose father suffered from haemophilia, marries a normal man. What percentage of their total progeny is expected to be affected by haemophilia?

Options

  1. A0%0\%
  2. B25%25\%
  3. C50%50\%
  4. D75%75\%

Correct answer

B. 25%25\%

Step-by-step solution

Haemophilia is an X-linked recessive disorder. Let the normal allele be XHX^{H} and the haemophilia allele be XhX^{h}.

The genotype of the woman's father is XhYX^{h}Y.

Since the woman is phenotypically normal but her father was haemophilic, she must have inherited the XhX^{h} chromosome from him. Thus, she is a carrier and her genotype is XHXhX^{H}X^{h}.

The woman marries a normal man, whose genotype is XHYX^{H}Y.

The cross is XHXh×XHYX^{H}X^{h} \times X^{H}Y.

The possible genotypes of the progeny are:
XHXHX^{H}X^{H} (Normal female) - 25%25\%
XHXhX^{H}X^{h} (Carrier female, phenotypically normal) - 25%25\%
XHYX^{H}Y (Normal male) - 25%25\%
XhYX^{h}Y (Haemophilic male) - 25%25\%

The only affected progeny is the haemophilic male (XhYX^{h}Y).

Therefore, the percentage of the total progeny expected to be affected by haemophilia is 25%25\%.

Answer: 25%25\%
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