The relative reactivities of acyl compounds towards nucleophilic...

The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of

Options

AAcyl chloride $>$ Ester $>$ Acid anhydride $>$ Amide
BAcyl chloride $>$ Acid anhydride $>$ Ester $>$ Amide
CEster $>$ Acyl chloride $>$ Amide $>$ Acid anhydride
DAcid anhydride $>$ Amide $>$ Ester $>$ Acyl chloride

Correct answer

B. Acyl chloride $>$ Acid anhydride $>$ Ester $>$ Amide

Step-by-step solution

Better is the leaving group higher will be the reactivity of acyl compounds towards nucleophilic acyl substitution. Weaker is the base, better is the leaving group. Weaker bases are derived from stronger acids.

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