NTA Abhyas JEE Main2020ChemistryCarboxylic Acid DerivativesPractice

Which of the following is most reactive towards nucleophilic substitution reaction?

Options

AEthyl acetate
BAcetic anhydride
CAcetamide
DAcetyl chloride

Correct answer

D. Acetyl chloride

Step-by-step solution

The order of reactivity of acid derivatives towards different reactions decreases in the order, R C O C l > ( R C O ) 2 O > R C O O R ′ > R C O N H 2 In other words, the reactivity decreases as the basicity of the leaving group increases i.e., C l - < R C O O - < R O - < N H 2 -

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