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NTA Abhyas 2020
Exam
NTA Abhyas
Year
2020
Subject
Chemistry
Chapter
Carboxylic Acid Derivatives

NTA Abhyas 2020 · Chemistry · Carboxylic Acid Derivatives

Which of the following functional groups is generally least...

Which of the following functional groups is generally least reactive towards nucleophilic substitution reactions?

Options

  1. AAmide
  2. BEster
  3. Cacid chloride
  4. DAcid Anhydride

Correct answer

A. Amide

Step-by-step solution

Reactivity order

R−cO∣∣−Cl>R−cO∣∣−o−cO∣∣−R>R−cO∣∣−OR>R−cO∣∣−NH2R - c\mathop{O}_{| |} - Cl > R - c\mathop{O}_{| |} - o - c\mathop{O}_{| |} - R > R - c\mathop{O}_{| |} - OR > R - c\mathop{O}_{| |} - {NH}_{2}

Reactivity for nucleophilic in decreasing order.
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