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JEE Biomolecules PYQs with Solutions

493 previous year questions from Biomolecules (JEE Main & Advanced Chemistry) with answers and solutions. Numbered list, year tags, and one-tap solutions — built for serious JEE / NEET practice.

493 questionsChemistry2007–2026Answers + solutions

About Biomolecules PYQs

Biomolecules has 493 previous year questions in the Quantrex Academy JEE Main & Advanced Chemistry bank. The 220 questions in this list come from JEE Main (195) and JEE Advanced (25), spanning 2007 to 2026. Each question opens on its own page with the options, the correct answer and the worked solution where available.

Questions by year (this list)

  • 2026: 27
  • 2025: 23
  • 2024: 23
  • 2023: 22
  • 2022: 24
  • 2021: 30
  • 2020: 15
  • 2019: 19
  • 2018: 9
  • 2017: 3
  • 2016: 5
  • 2015: 4

Biomolecules questions with solutions

1

A known artificial sweetener X is composed of 4-chloro-4-deoxy- α -D-galactose and 1,6-dichloro-1,6-dideoxy- β -D-fructose joined by a glycosidic linkage. Structure of D-galactose

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2

The correct statement(s) regarding sugars is(are) Given: Specific rotations of L-( - )-glucose and L-( + )-fructose are -52.5^∘ and +92.5^∘ , respectively.

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3

In the following reaction sequence, major products X and Y are acyclic monomers. 500 mol of X completely reacts with 500 mol of Y to give 1 mol of a single biodegradable acyclic

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4

The incorrect statement from the following with respect to carbohydrates is:

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5

Which of the following amino acid will give violet coloured complex with neutral ferric chloride solution?

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6

Consider the following reactions. Total number of electrons in the π bonds and lone pair of electrons in the product (X) is :

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7

Match the LIST-I with LIST-II List-I Deficiency Disease List-II Vitamin A. Scurvy I. Pyridoxine B. Convulsions II. Vitamin A C. Cheilosis III. Ascorbic Acid D. Xerophthalmia IV.

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8

Match the LIST-I with LIST-II List-I Amino acid List-II Positive reaction/Test for functional group present in side chain of amino acid A. Glutamine I. Hinsberg's test B. Lysine

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9

Sucrose hydrolyses in acidic medium into glucose and fructose by first order rate law with t_ 1/2 = 3 hour. The percentage of sucrose remaining after 6 hours is _______. (Nearest

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10

Identify the incorrect statement about tertiary structure of proteins.

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11

Given below are two statements : Statement I: The two cyclic forms of D-(+)-glucose (α and β anomers differing at C1 hydroxyl orientation) are two anomers of D-(+)-glucose.

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12

Identify the correct statements. A. Glucose exists in two anomeric forms. B. Anomers of glucose differ in configuration at C -1 in cyclic hemiacetal structure. C. Melting point of

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13

A D-aldotetrose on oxidation with concentrated HNO_3 resulted in optically inactive dicarboxylic acid. The structure of the D-aldotetrose is:

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14

Given below are two statements: Statement I: The structure of Maltose is given below: Maltose is a non-reducing sugar. Statement II: The structure of Lactose is given below

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15

Match the LIST-I with LIST-II List-I Name of amino acid List-II One letter symbol/type A. Arginine I. D/Non-essential B. Aspartic acid II. R/Essential C. Lysine III.

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16

Identify the correct pair having amino acid (A) and the hormone (B) that is iodinated derivative of the amino acid (A). (T and Y represent one letter code for amino acids) Amino

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17

Match List - I with List - II. List - I Vitamin List - II Name A. Vitamin B_1 I. Pyridoxine B. Vitamin B_2 II. Ascorbic acid C. Vitamin B_6 III. Thiamine D. Vitamin C IV.

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18

Structures of four disaccharides are given below. Among the given disaccharides, the non-reducing sugar is :

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19

In the given pentapeptide, find out an essential amino acid (Y) and the sequence present in the pentapeptide: Choose the correct answer from the options given below:

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20

The number of possible tripeptides formed involving alanine (ala), glycine (gly) and valine (val), where no amino acid has been used more than once is:

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21

A student is given one compound among the following compounds that gives positive test with Tollen's reagent. The compound is :

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22

Both human DNA and RNA are chiral molecules. The chirality in DNA and RNA arises due to the presence of

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23

From the given following (A to D) cyclic structures, those which will not react with Tollen's reagent are :

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24

Match List - I with List - II. List - I List - II Reaction of Glucose with Product formed A. Hydroxylamine I. Gluconic acid B. Br_ 2 water II. Glucose pentacetate C. Excess acetic

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25

Given below are two statements: Statement I : Sucrose is dextrorotatory. However, sucrose upon hydrolysis gives a solution having mixture of products. This solution shows

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26

The correct statements are : A. Activation energy for enzyme catalysed hydrolysis of sucrose is lower than that of acid catalysed hydrolysis. B. During denaturation, secondary and

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27

Identify the correct statements. A. Arginine and Tryptophan are essential amino acids. B. Histidine does not contain heterocyclic ring in its structure. C. Proline is a six

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28

A linear octasaccharide (molar mass =1024 ~g ~mol^ -1 ) on complete hydrolysis produces three monosaccharides: ribose, 2-deoxyribose and glucose. The amount of 2-deoxyribose

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29

Choose the correct option for structures of A and B , respectively.

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30

Given below are two statements : Statement (I) : On hydrolysis, oligo peptides give rise to fewer number of α -amino acids while proteins give rise to a large number of β -amino

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31

Given below are two statements: Statement I : D-(+)-glucose +D-(+) fructose -H_2 O sucrose Statement II : Invert sugar is formed during sucrose hydrolysis. In the light of the

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32

A dipeptide, " x " on complete hydrolysis gives " y " and " z ". " y " on treatment with aq. HNO_2 produces lactic acid. On the other hand " z " on heating gives the following

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33

Identify the pair of reactants that upon reaction, with elimination of HCl will give rise to the dipeptide Gly-Ala.

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34

The total number of hydrogen bonds of a DNA-double Helix strand whose one strand has the following sequence of bases is_______. 5^ - G - G-C-A-A-A-T-C-G-G-C-T-A-3'

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35

Fat soluble vitamins are : A. Vitamin B_1 B. Vitamin C C. Vitamin E D. Vitamin B_ 12 E. Vitamin K Choose the correct answer from the options given below :

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36

Given below are two statements : Statement I : Wet cotton clothes made of cellulose based carbohydrate takes comparatively longer time to get dried than wet nylon polymer based

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37

Which of the following is the correct structure of L-fructose?

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38

A tetrapeptide " x " on complete hydrolysis produced glycine (Gly), alanine (Ala), valine (Val), leucine (Leu) in equimolar proportion each. The number of tetrapeptides

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39

Identify the correct statement among the following:

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40

Identify the essential amino acids from below : (A) Valine (B) Proline (C) Lysine (D) Threonine (E) Tyrosine Choose the correct answer from the options given below :

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41

Match List - I with List - II. \( array l List - I (Carbohydrate) array array l List - II (Linkage Source) array (A) Amylose (I) β-C_1-C_4 , plant (B) Cellulose (II) α-C_1-C_4

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42

Match List - I with List - II. Choose the correct answer from the options given below :

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43

Identify correct conversion during acidic hydrolysis from the following : (A) starch gives galactose. (B) cane sugar gives equal amount of glucose and fructose. (C) milk sugar

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44

Given below are two statements: Statement I : D-glucose pentaacetate reacts with 2, 4-dinitrophenylhydrazine Statement II : Starch, on heating with concentrated sulfuric acid at

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45

Choose the correct answer from the options given below :

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46

The carbohydrate "Ribose" present in DNA, is A. A pentose sugar B. present in pyranose from C. in "D" configuration D. a reducing sugar, when free E. in ∝ -anomeric form Choose

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47

The α -Helix and β - Pleated sheet structures of protein are associated with its :

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48

Given below are two statements: Statement I: Fructose does not contain an aldehydic group but still reduces Tollen's reagent Statement II: In the presence of base, fructose

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49

Identify the number of structure/s from the following which can be correlated to D-glyceraldehyde.

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50

Which of the following acids is a vitamin?

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51

For a double strand DNA, one strand is given below: The amount of energy required to split the double strand DNA into two single strands is _______ kcal mol^ -1 . [Given: Average

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52

The incorrect statement about Glucose is :

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53

Total number of essential amino acid among the given list of amino acids is _______ Arginine, Phenylalanine, Aspartic acid, Cysteine, Histidine, Valine, Proline

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54

The total number of carbon atoms present in tyrosine, an amino acid, is _______

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55

The incorrect statement regarding the given structure is

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56

The incorrect statements regarding enzymes are : (A) Enzymes are biocatalysts. (B) Enzymes are non-specific and can catalyse different kinds of reactions. (C) Most Enzymes are

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57

DNA molecule contains 4 bases whose structure are shown below. One of the structures is not correct, identify the incorrect base structure.

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58

Coagulation of egg, on heating is because of :

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59

Which of the following gives a positive test with ninhydrin?

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60

Match List I with List II \( List - I List - II A. α - Glucose and α - Galactose I. Functional isomers B. α - Glucose and β - Glucose II. Homologous C. α - Glucose and α

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61

Vanillin compound obtained from vanilla beans, has total sum of oxygen atoms and \(π\) electrons is ______

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62

Which of the following is the correct structure of L-Glucose?

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63

The number of tripeptides formed by three different amino acids using each amino acid once is _______.

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64

If one strand of a DNA has the sequence ATGCTTCA, sequence of the bases in complementary strand is:

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65

From the vitamins A, B _ 1 , B _ 6 , B _ 12 , C, D, E and K , the number vitamins that can be stored in our body is ______.

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66

Match List I with List II List-I List-II A. Glucose/ NaHCO _ 3 / ∆ I. Gluconic acid B. Glucose/ HNO _ 3 II. No reaction C. Glucose/ HI / ∆ III. n -hexane D. Glucose/Bromine water

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67

The total number of correct statements, regarding the nucleic acids is _________. A. RNA is regarded as the reserve of genetic information. B. DNA molecule self-duplicates during

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68

Sugar which does not give reddish brown precipitate with Fehling's reagent is:

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69

Match List I with List II Choose the correct answer from the options given below :-

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70

Type of amino acids obtained by hydrolysis of proteins is :

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71

Match List I with List I List I (Substances) List II (Element Present) A. Ziegler catalyst I. Rhodium B. Blood Pigment II. Cobalt C. Wilkinson catalyst III. Iron D. Vitamin B12

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72

Which structure of protein remains intact after coagulation of egg white on boiling?

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73

Two nucleotides are joined together by a linkage known as :

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74

A disaccharide X cannot be oxidised by bromine water. The acid hydrolysis of X leads to a laevorotatory solution. The disaccharide X is

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75

Which is not true for arginine?

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76

The naturally occurring amino acid that contains only one basic functional group in its chemical structure is

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77

In an oligopeptide named Alanylglycylphenyl alanyl isoleucine, the number of sp ^ 2 hybridised carbons is _____.

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78

The one that does not stabilize 2 ^ ∘ and 3 ^ ∘ structures of proteins is

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79

Match List I with List II List I Natural amino acid List II One Letter Code (A) Glutamic acid (I) Q (B) Glutamine (II) W (C) Tyrosine (III) E (D) Tryptophan (IV) Y Choose the

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80

Sulphur (S) containing amino acids from the following are: (a) isoleucine (b) cysteine (c) lysine (d) methionine (e) glutamic acid

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81

Match List-I with List-II. List-I Natural Amino acid List-II One Letter Code (A) Arginine (I) D (B) Aspartic acid (II) N (C) Asparagine (III) A (D) Alanine (IV) R Choose the

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82

Match List I and List II List I Vitamin List II Deficiency disease A Vitamin A I Beri-Beri B Thiamine II Cheilosis C Ascorbic acid III Xerophthalmia D Riboflavin IV Scurvy Choose

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83

All structures given below are of vitamin C . Most stable of them is:

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84

Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): α -halocarboxylic acid on reaction with dil. NH _ 3 gives

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85

The correct representation in six membered pyranose form for the following sugar [ X ] is

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86

Match List I and List II List I List II Test Functional group / Class of Compound (A) Molisch's Test (I)Peptide (B) Biuret Test (II)Carbohydrate (C) Carbylamine Test (III)

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87

Compound A, C _ 5 H _ 10 O _ 5 , given a tetraacetate with AC _ 2 O and oxidation of A with Br _ 2 - H _ 2 O gives an acid, C _ 5 H _ 10 O _ 6 . Reduction of A with HI gives

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88

A protein ‘ X ’ with molecular weight of 70, 000u , on hydrolysis gives amino acids. One of these amino acid is

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89

A short peptide on complete hydrolysis produces 3 moles of glycine (G) , two moles of leucine (L) and two moles of valine (V) per mole of peptide. The number of peptide linkages

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90

Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): Ketoses give Seliwanoff’s test faster than Aldoses.

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91

Following tetrapeptide can be represented as ( F, L, D, Y, I, Q, P are one letter codes for amino acids)

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92

Number of cyclic tripeptides formed with 2 amino acids A and B is:

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93

Match items of Row I with those of Row II. Row I: (P) (Q) (R) (S) Row II: (i) α ‐ D ‐ ( — ) Fructofuranose. (ii) β ‐ D ‐ ( — ) Fructofuranose. (iii) α ‐ D ‐ ( ‐ ) Glucopyranose.

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94

An athlete is given 100g of glucose ( C _ 6 H _ 12 O _ 6 ) for energy. This is equivalent to 1800kJ of energy. The 50 % of this energy gained is utilized by the athlete for sports

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95

Total number of tripeptides possible by mixing of valine and proline is ________ .

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96

Treatment of D -glucose with aqueous NaOH results in a mixture of monosaccharides, which are

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97

Given below are two statements. One is labelled as Assertion A and the other is labelled as Reason R . Assertion A : Amylose is insoluble in water. Reason R : Amylose is a long

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98

In a linear tetrapeptide (Constituted with different amino acids), (number of amino acids) - (number of peptide bonds) is

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99

The formulas of A and B for the following reaction sequence are

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100

For the below given cyclic hemiacetal (X) , the correct pyranose structure is

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101

Match List-I with List-II List-I List-II A Glucose + HI I Gluconic acid B Glucose + Br _ 2 water II Glucose pentacetate C Glucose + acetic anhydride III Saccharic acid D Glucose +

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102

A sugar ' X ' dehydrates very slowly under acidic condition to give furfural which on further reaction with resorcinol gives the coloured product after sometime. Sugar

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103

Optical activity of an enantiomeric mixture is + 12 . 6 ° and the specific rotation of (+) isomer is + 30 ° . The optical purity is____ %

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104

Animal starch is the other name of

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105

Which of the following is reducing sugar?

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106

Glycosidic linkage between C _ 1 of α -glucose and C _ 2 of β -fructose is found in

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107

During the denaturation of proteins, which of these structures will remain intact ?

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108

The structure of protein that is unaffected by heating is :

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109

Sugar moiety in DNA and RNA molecules respectively are

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110

C _ 6 H _ 12 O _ 6 Zymase ⟶ A → _ ∆ ^ NaOI B + CHI _ 3 The number of carbon atoms present in the product B is

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111

When sugar ' X ' is boiled with dilute H _ 2 SO _ 4 in alcoholic solution, two isomers ' A ' and ' B ' are formed. ' A ' on oxidation with HNO _ 3

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112

2 . 5g of protein containing only glycine ( C _ 2 H _ 5 NO _ 2 ) is dissolved in water to make 500mL of solution. The osmotic pressure of this solution at 300K is found to be 5 .

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113

Stability of α - Helix structure of proteins depends upon

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114

Given below are two statements. Statement I: Maltose has two α - D - glucose units linked at C _ 1 and C _ 4 and is a reducing sugar. Statement II: Maltose has two

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115

Which one of the following is a water soluble vitamin, that is not excreted easily?

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116

The number of oxygen present in a nucleotide formed from a base, that is present only in RNA is

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117

How many of the given compounds will give a positive Biuret test____? Glycine, Glycylalanine, Tripeptide, Biuret

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118

In alanylglycylleucylalanylvaline the number of peptide linkages is:

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119

A polysaccharide ' X ' on boiling with dil H _ 2 SO _ 4 at 393K under 2 - 3atm pressure yields ' Y ' ' Y ' on treatment with bromine water gives gluconic

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120

Given: The compound (s), which on reaction with HNO _ 3 will give the product having degree of rotation, [α]D = - 52 .7 ° is (are)

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